Clinical Pathway: multidisciplinary task-oriented and time-sequenced plan of care which provides guidance in the care of patients with a specific clinical problem in an effort to improve quality of care and reduce unnecessary variation. Pathways translate guidelines and the latest literature into local practice; can also reflect commonly accepted care standards when evidence is lacking. Use of a pathway is not mandatory but is strongly encouraged.

Clinical Practice Guideline:  define the role of specific diagnostic and treatment modalities in the diagnosis and management of patients, issued by a third-party organization. These are statements that contain recommendations based on evidence from rigorous systematic review and synthesis of published literature without modification by local or regional experts or practice. (Definition adapted from the National Center for Complementary and Integrative Health within NIH)

Clinical Protocol: A set of assessments and interventions constrained by rules and algorithms that define the care of a patient with a specific condition and requires an order by a prescriber to be initiated. These are posted in PolicyStat and may be incorporated into clinical pathways. Questions may be directed to Donnetta Perkins as this process is being revised.

For an outline of the process of developing a pathway at Children's, please take a look at our User's Guide. If you are ready to develop a pathway, please fill out an Improvement Team Charter and the Pathway Steering Committee will help get you started in the right direction.

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Learn More Here (Children's Hospital providers only)

Pathway Steering Committee Chairs

Lauren J. Maskin, M.D.
Kelsey Zindel, DNP, APRN-NP, CPNP-AC/PC


Clinical Pathways User’s Guide
Executive Summary
Improvement Team Charter

PI Resource


Children’s Nebraska AgileMD Pathways

Children’s Nebraska is transitioning pathways into AgileMD. AgileMD pathways are Epic-integrated, allowing providers to have evidence-based guidance with algorithms, clinical calculators, and orders all within their clinical workflow.

Children’s Nebraska AgileMD Pathways Here

Find a Clinical Pathway

for Clinical Pathways

Airway Bleeding on ECMO


Aspirin Initiation for High-Risk Cardiac Patients




COVID-19 Pathways

Diabetic Ketoacidosis (DKA)

Dislodged G-Tube

Distal Torus Fracture

Eating Disorders

Febrile Infant


Foreign Body Ingestion

Heated High Flow


Hyperglycemia Hyperosmolar Syndrome

Junctional Ectopic Tachycardia (JET)

Kawasaki Disease


Musculoskeletal Infection

Otitis Media (Acute)


Physical Abuse, Suspected

Pneumonia, Community Acquired (CAP)

Pulmonary Embolism

Renal Calculi

Sepsis – ED

Sepsis – Inpatient

Sexual Abuse, Suspected

Sickle Cell Disease Pain

Single Ventricle Feeding Tube Weaning

Sinusitis, Acute Bacterial

Skin & Soft Tissue Infection (SSTI)

Spine Deformity Surgery – High-Risk

Spine Deformity Surgery – Low-Risk

Status Epilepticus





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